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이동욱 / Lee, Dong Wook
  • 전남대학교 바이오에너지공학과 조교수
  • 식물시스템생물학
1995-2000 : 한동대학교, 생물식품공학부 (현 생명과학부), 학사
2000-2002 : 한동대학교, 생명과학과, 석사
2002-2008 : 포항공과대학교, 분자생명과학부, 박사 (지도교수: 황인환)
2008. 02 ~ 2009. 06: 박사후 연구원, 포항공과대학교, 생명과학과
2009. 07 ~ 2010. 07: 박사후 연구원, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, LA, CA, USA
2010. 09 ~ 2014. 06: 박사후 연구원, 포항공과대학교, 융합생명공학부
2014. 06 ~ 2019. 08: 연구조교수, 포항공과대학교, 융합생명공학부
2019. 09 ~ 현재: 조교수, 전남대학교, 바이오에너지공학과
식물 분자세포생물학, 막 생물학, 분자농업 (molecular farming)

1) 식물세포 소기관 (subcellular organelles) 발달 기작

2) 식물 엽록체 및 미토콘드리아로의 단백질 이동 및 수송 기작

3) 단백질의 막 (membrane) 통과 및 막으로의 삽입 기작

4) 세포 재설계 (cellular reprogramming)을 통한 식물 바이오매스 증진

5) 식물시스템을 이용한 유용 단백질 생산

1. Geem, K.R., Song, Y., Hwang, I., Bae, H.J., and Lee, D.W. (2021) Production of Gloeophyllum trabeum Endoglucanase Cel12A in Nicotiana benthamiana for Cellulose Degradation. Front Plant Sci. 11:64. 12:696199.

2. Lee D,W., and Hwang, I. (2021) Understanding the evolution of endosymbiotic organelles based on the targeting sequences of organellar proteins. New Phytologist. 230(3):924-930.

3. Razzak, M.A., Lee, D.W., Lee, J., and Hwang, I. (2020) Overexpression and purification of Gracilariopsis chorda carbonic anhydrase (GcCAα3) in Nicotiana benthamiana, and its immobilization and use in CO2 hydration reactions. Front Plant Sci. 11:563721.

4. Kumari, M., Lee, J., Lee, D.W., and Hwang, I. (2020) High-level production in a plant system of a thermostable carbonic anhydrase and its immobilization on microcrystalline cellulose beads for CO2 capture. Plant Cell Reports. 39:1317-1329.

5. Lee, D.W., and Hwang, I. (2020) A Fight between Plants and Pathogens for the Control of Chloroplasts. Cell Host & Microbe. 28(3):351-352.

6. Lee, D.W., and Hwang, I. (2020) Liquid-liquid phase transition as a new means in protein targeting in chloroplasts. Molecular Plant. 13(5):679-681.

7. Lee, D.W., Lee, S., Min, C.K., Park, C., Kim, J.M., Hwang, C.S., Park, S.K., Cho, N.H., and Hwang, I. (2020) Cross-Species Functional Conservation and Possible Origin of the N-Terminal Specificity Domain of Mitochondrial Presequences. Front Plant Sci. 13;11:64.

8. Islam, M.R., Son, N., Lee, J., Lee, D.W., Sohn, E.J., and Hwang, I. (2019) Production of bacteriophage-encoded endolysin, LysP11, in Nicotiana benthamiana and its activity as a potent antimicrobial agent against Erysipelothrix rhusiopathiae. Plant Cell Reports, 38(12):1485-1499.

9. Lee, D.W., and Hwang, I. (2019) Protein import into chloroplasts via the Tic40-dependent and -independent pathways depends on the amino acid composition of the transit peptide. Biochem Biophys Res Commun. 518(1):66-71.

10. Lee, D.W., Lee, S., Lee, J., Woo, S., Razzak, M.A., Vitale, A., and Hwang, I. (2019) Molecular Mechanism of the Specificity of Protein Import into Chloroplasts and Mitochondria in Plant Cells. Molecular Plant. 12(7):951-966.

11. *Nguyen, B. v., *Lee, D.W., Lee, S. Hwang, I., and Cheong, G.W. (2019) Structural analysis of Tha4, a twin-arginine translocase protein localized in plant thylakoid membranes. Journal of Plant Biology. 62:129-136. (* equal contribution).

12. Razzak, M.A., Lee, J., Lee, D.W., Kim, J.H., Yoon, H.S., and Hwang, I. (2019) Expression of seven carbonic anhydrases in red alga Gracilariopsis chorda and their subcellular localization in a heterologous system, Arabidopsis thaliana. Plant Cell Reports, 38(2):147-159.

13. Geem, K.R., Kim, D.H., Lee, D.W., Kwon, Y., Lee, J., Kim, J.H., and Hwang, I. (2019) Jasmonic acid-inducible TSA1 facilitates ER body formation. Plant J. 97(2):267-280.

14. Lee, D.W., and Hwang, I. (2018) Evolution and Design Principles of the Diverse Chloroplast Transit Peptides. Mol Cells. 41(3):161-167.

15. Lee, D.W., Yoo, Y.J., Razzak, M.A., and Hwang, I. (2018) Prolines in transit peptides are crucial for efficient preprotein translocation into chloroplasts. Plant Physiol. 176(1):663-677.

16. *Razzak, M.A., *Lee D.W., Yoo, Y.J., and Hwang, I. (2017) Evolution of rubisco complex small subunit transit peptides from algae to plants. Scientific reports. 7(1):9279. (* equal contribution).

17. Jung, J.Y., Lee, D.W., Ryu, S.B., Hwang, I., and Schachtman, D.P. (2017) SCYL2 genes are involved in clathrin-mediated vesicle trafficking and essential for plant growth. Plant Physiol. 175(1):194-209.

18. *Lee, D.W., *Lee, J., and Hwang, I. (2017) Sorting of nuclear-encoded chloroplast membrane proteins. Curr. Opin. Plant Biol. 40:1-7 (* equal contribution).

19. Lee, D.W., Kim, S. J., Oh, Y. J., Choi, B., Lee, J., and Hwang, I. (2016) Arabidopsis BAG1 functions as a cofactor in Hsc70-mediated proteasomal degradation of unimported plastid proteins. Molecular Plant. 9(10):1428-1431.

20. Kim, D., Beck, B.R., Lee, S.M., Jeon, J., Lee, D.W., Lee, J.I., and Song, S.K. (2016) Pellet feed adsorbed with the recombinant Lactococcus lactis BFE920 expressing SiMA antigen induced strong recall vaccine effects against Streptococcus iniae infection in olive flounder (Paralichthys olivaceus). Fish Shellfish Immunol. 55:374-383.

21. Yoo, Y.J., Lee, H.K., Han, W., Kim, D.H., Lee, M.H., Jeon, J., Lee, D.W., Lee, J., Lee, Y., Lee, J., Kim, J.S., Cho, Y., Han, J.K., and Hwang, I. (2016) Interactions between Transmembrane Helices within Monomers of the Aquaporin AtPIP2;1 Play a Crucial Role in Tetramer Formation. Molecular Plant. 9(7):1004-1017.

22. Oh, Y. J., Kim, H., Seo, S. H., Hwang, B. G., Chang, Y. S., Lee, J., Lee, D. W., Sohn, E. J., Lee, S. J., Lee, Y., and Hwang, I. (2015) Cytochrome b5 reductase 1 triggers serial reactions that lead to iron uptake in plants. Molecular Plant. 9(4):501-13.

23. Lee, D. W., Woo, S., Geem, K. R., and Hwang, I. (2015) Sequence Motifs in Transit Peptides Act as Independent Functional Units and Can Be Transferred to New Sequence Contexts. Plant Physiol. 169(1):471-84.

24. Kim, Y., Lee, G., Jeon, E., Sohn, E.J., Lee, Y., Kang, H., Lee, D.W., Kim, D.H., and Hwang, I. (2014) The immediate upstream region of the 5'-UTR from the AUG start codon has a pronounced effect on the translational efficiency in Arabidopsis thaliana. Nucleic Acids Res. 42(1):485-98.

25. Lee, D.W., Jung, C., and Hwang, I (2013) Cytosolic events involved in chloroplast protein targeting. Biochim Biophys Acta. 1833(2): 245-252.

26. Lee, Y.J., Jang, M., Song, K., Kang, H., Lee, M.H., Lee, D.W., Zouhar, J., Rojo, E., Sohn, E.J., and Hwang I (2013) Functional identification of sorting receptors involved in trafficking of soluble lytic vacuolar proteins in vegetative cells of Arabidopsis. Plant Physiol. 161(1): 121-133.

27. Kang, H., Kim, S.Y., Song, K., Sohn, E.J., Lee, Y., Lee, D.W., Hara-Nishimura, I., and Hwang, I (2012) Trafficking of Vacuolar Proteins: The Crucial Role of Arabidopsis Vacuolar Protein Sorting 29 in Recycling Vacuolar Sorting Receptor. Plant Cell, 24(12): 5058-5073.

28. Lee, S., Lee, D.W., Yoo, Y.J., Duncan, O., Oh, Y., Lee, Y.J., Lee, G., Whelan J., and Hwang I (2012) Mitochondrial Targeting of the Arabidopsis F1-ATPase γ-Subunit via Multiple Compensatory and Synergistic Presequence Motifs. Plant Cell, 24(12):5037-57.

29. Lee, D. W., and Hwang, I (2011) Transient expression and analysis of chloroplast proteins in Arabidopsis protoplasts. Methods in Molecular Biology, 774:59-71.

30. Oh, S., E, X., Ni, D., Pirooz, S.D., Lee, J.Y., Lee, D., Zhao, Z., Lee, S., Lee, H., Ku, B., Kowalik, T., Martin, S.E., Oh, B.H., Jung, J.U., and Liang, C. (2011) Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis. Cell Death Differ. 18(3):452-464.

31. Lee S., Lee D.W., Lee, Y., Mayer, U., Stierhof, Y.D., Lee, S., Jurgens, G., and Hwang, I. (2009) Heat shock protein cognate 70-4 and an E3 ubiquitin ligase, CHIP, mediate plastid-destined precursor degradation through the ubiquitin-26S proteasome system in Arabidopsis. Plant Cell. 21(12):3984-4001.

32. Lee, D.W., Lee, S., Oh, Y.J., and Hwang, I. (2009) Multiple sequence motifs in the rubisco small subunit transit peptide independently contribute to Toc159-dependent import of proteins into chloroplasts. Plant Physiol. 151(1):129-141.

33. Kikuchi, S., Oishi, M., Hirabayashi, Y., Lee, D.W., Hwang, I., and Nakai, M. (2009) A 1-megadalton translocation complex containing Tic20 and Tic21 mediates chloroplast protein import at the inner envelope membrane. Plant Cell. 21(6):1781-1797.

34. Agne, B., Infanger, S., Wang, F., Hofstetter, V., Rahim, G., Martin, M., Lee, D.W., Hwang, I., Schnell, D., and Kessler, F. (2009) A toc159 import receptor mutant, defective in hydrolysis of GTP, supports preprotein import into chloroplasts. J Biol Chem. 284(13):8670-8679.

35. *Lee, D.W., *Kim, J.K., Lee, S., Choi, S., Kim, S., and Hwang, I. (2008) Arabidopsis nuclear-encoded plastid transit peptides contain multiple sequence subgroups with distinctive chloroplast-targeting sequence motifs. Plant Cell. 20(6): 1063-1622. (* equal contribution)

36. Lee, G.J., Kim, H., Kang, H., Jang, M., Lee, D.W., Lee, S., and Hwang, I. (2007) EpsinR2 interacts with clathrin, AP-3, AtVTI12, and PtdIns(3)P. Implications for EpsinR2 function in protein trafficking in plant cells. Plant Physiol. 143(4): 1561-1575.

37. Lee, D.W., Lee, S., Lee, G.J., Lee, K.H., Kim, S., Cheong, K.W., and Hwang, I (2006) Functional characterization of sequence motifs in the transit peptide of Arabidopsis small subunit of Rubisco. Plant Physiol. 140(2): 466-483.

38. Lee, Y.J., Sohn, E.J., Lee, K.H., Lee, D.W., and Hwang, I. (2004) The transmembrane domain of AtToc64 and its C-terminal lysine-rich flanking region are targeting signals to the chloroplast outer envelope membrane. Mol Cells. 17(2):281-291.

39. Park, C.H., Lee, D.W., Kang, T.B., Lee, K.H., Yoon, T.J., Kim, J.B., Do, M.S., and Song, S.K. (2001) cDNA cloning and sequence analysis of the lectin genes of the Korean mistletoe (Viscum album coloratum). Mol Cells. 12(2):215-20.